Designing and developing implantable medical devices involves navigating complex technical challenges while ensuring the highest standards of patient safety and device performance. For companies like Injectsense, creating an implantable device that can function reliably within the human body is an intricate task that requires expertise in multiple areas, including biocompatibility, miniaturization, and real-time data transmission. In this article for Medical Design and Development, Promex COO Dave Fromm and Injectsense CEO Ariel Cao use the companies’ collaboration on the IOP-Connect implantable eye pressure sensor as an example to guide readers through key considerations for designing, developing, and manufacturing implantable devices.